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desvenlafaxine will increase the amount or impact of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Desvenlafaxine inhibits CYP2D6; with better desvenlafaxine doses (ie, four hundred mg) lower the CYP2D6 substrate dose by approximately fifty%; no dosage adjustment essential with desvenlafaxine doses seven consecutive